Key result
The comorbidity of non-alcoholic fatty liver disease and hypertension is driven by insulin resistance, lipid metabolism disorders, pro-inflammatory cytokine imbalance, and oxidative stress.
Why the study?
Non-alcoholic fatty liver disease and hypertension frequently present as comorbidities and can independently impair renal function.
This review highlights the complex pathophysiological interactions between NAFLD, hypertension, and chronic kidney disease, emphasizing the roles of insulin resistance, systemic inflammation, and adipokines in cardiovascular risk.
Highlights need for renal monitoring in NAFLD-hypertension comorbidity; leaves open targeted interventions on shared pathways.
The article presents the main aspects of the pathogenesis of comorbidity of non-alcoholic fatty liver disease and hypertension. These diseases are very often presented as comorbidities in a large number of patients and can independently impair renal function. According to the literature and the results of our own research, the role of insulin resistance, disorders of lipid and carbohydrate metabolism, cytokine imbalance, disorders of the antioxidant defense system in the pathogenesis of this comorbidity was analyzed. The effect of hypoadictinemia and increased blood levels of fetuin-A and cytokeratin-18 on this comorbidity was also assessed. The independent effect of non-alcoholic fatty liver disease on renal function, arterial stiffness and the occurrence of diastolic heart function was analyzed. The interaction between non-alcoholic fatty liver disease and hypertension depending on the presence of chronic kidney disease was also evaluated.
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Prosolenko et al. (2022) conducted a review in Non-alcoholic fatty liver disease (NAFLD) and hypertension. Comorbidity of NAFLD and hypertension was evaluated. The comorbidity of non-alcoholic fatty liver disease and hypertension is driven by insulin resistance, lipid metabolism disorders, pro-inflammatory cytokine imbalance, and oxidative stress.
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