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October 30, 2006The Prostate

Sulfasalazine‐induced cystine starvation: Potential use for prostate cancer therapy

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Authors

DDDaniel W. DoxseeBC Cancer AgencyPGPeter W. GoutDartmouth CollegeTKTakeshi KuritaTokyo Medical and Dental University

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Doxsee et al. (2006) studied this question.

synapsesocial.com/papers/6a74ef268d2049c8dd034a04https://doi.org/10.1002/pros.20508
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.1998 · 742 citations
  2. 2Cystine-Glutamate Transporter <i>SLC7A11</i> in Cancer Chemosensitivity and Chemoresistance2005 · 343 citations
  3. 3Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state1997 · 126 citations
  4. 4Role of cystine transport in intracellular glutathione level and cisplatin resistance in human ovarian cancer cell lines2003 · 198 citations