Drug-behavior interactions in persons with mental retardation and developmental disabilities

Treatment for aberrant behavior in persons diagnosed with developmental disabilities typically involves either behavioral interventions or medication. Often, the treatment is a combination of the two. Schroeder and coworkers (Schroeder et al. [1983] Adv Learn Behav Disabil 2:179–225) outlined criteria for the evaluation of the combination of behavioral and drug interventions in persons with developmental disabilities. A review of the research that examined the combination of drug and behavior interactions since 1983, using the Schroeder et al. criteria, is provided. An evaluation of research since 1983 that examined medication effects on multiple dependent measures and between multiple medications, using the criteria for medication research by Sprague and Werry (Sprague and Werry [1971] Int Rev Res Ment Retard vol. 5) is also provided. Additionally, the final section provides a list of recommendations and criteria for practitioners and researchers when conducting or evaluating research designed to examine medication effects on multiple variables in persons with developmental disabilities. MRDD Research Reviews 1999;5:322–334.