Key result
Aminophylline infusion was used as a potential reversal agent for ticagrelor-induced incessant Cheyne-Stokes respiration and heart rate instability in a patient with heart failure and NSTEMI.
Case Report (n=1)
Aminophylline infusion may serve as a potential reversal agent for ticagrelor-induced respiratory and arrhythmic adverse effects.
Aminophylline may reverse ticagrelor-induced Cheyne-Stokes in HF; leaves open whether this warrants prospective trials.
Dyspnea and bradyarrhythmias are frequent adverse effects (AEs) of ticagrelor. AEs commonly occur within the first week of therapy, are dose related and usually mild, but sometimes they may cause drug discontinuation. Currently, the exact mechanisms of ticagrelor-related AEs have not been definitively explained. In addition to the prevalent theory of adenosine overload, other reasonable mechanism like a direct central stimulation hypothesis was suggested. We present a case of incessant Cheyne-Stokes respiration associated with heart rate instability in patient with congestive heart failure and non-ST-segment elevation myocardial infarction, supporting the use of aminophylline as a potential reversal agent of ticagrelor-related AEs.
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Conte et al. (2017) conducted a case report in Ticagrelor-induced arrhythmias and Cheyne-Stokes respiration (n=1). Aminophylline infusion was evaluated on Reversal of ticagrelor-related adverse effects. Aminophylline infusion was used as a potential reversal agent for ticagrelor-induced incessant Cheyne-Stokes respiration and heart rate instability in a patient with heart failure and NSTEMI.
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