Key result
In patients with coronary artery disease, serum nitrotyrosine positively correlated with MMP-9 activity (r=0.54, p=0.01), and lipid parameters correlated with nitrotyrosine and MMP-2 activity.
Population
36 consecutive patients with single-vessel coronary artery disease and Class II or III stable angina…
Design
Cross-sectional
Authors
Loading...
Correlations between nitrotyrosine and MMP activity in CAD are hypothesis-generating; should not yet change clinical practice.
Cross-Sectional (n=36)
No
Effect estimate: r=0.54
p-value: p=0.01
In patients with coronary artery disease, serum nitrotyrosine correlates with MMP-9 activity, lipid parameters, and reduced left ventricular ejection fraction, suggesting a link between hyperlipidemia, nitro-oxidative stress, and matrix metalloproteinase activation.
Bencsik et al. (2015) conducted a cross-sectional in Coronary artery disease (n=36). Serum nitrotyrosine and MMP activity was evaluated on Correlation between serum nitrotyrosine and MMP-9 activity (r=0.54, p=0.01). In patients with coronary artery disease, serum nitrotyrosine positively correlated with MMP-9 activity (r=0.54, p=0.01), and lipid parameters correlated with nitrotyrosine and MMP-2 activity.