Key result
Long-term n-3 PUFAs reduce total homocysteine post-MI vs. corn oil without altering inflammatory markers.
RCT (n=300)
Double-blind
Randomized
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We hypothesized that n-3 polyunsaturated fatty acids (n-3 PUFAs) as compared to corn oil administered for 1 year following an acute myocardial infarction (MI) may reduce plasma total homocysteine (p-tHcy), ultrasensitive C-reactive protein (microCRP), and the adhesive properties of the endothelium, expressed as soluble E-selectin (sE-selectin) and soluble intercellular adhesion molecule-1 (sICAM-1). In a prospective, randomised, double-blind study, 300 acute MI patients were allocated to highly concentrated n-3 PUFAs (n = 150) or corn oil (n = 150). After 1 year on treatment there was an intergroup difference in p-tHcy in favour of the n-3 group (n = 118), p = 0.022. However, sE-selectin, sICAM-1 and microCRP were unaffected by the treatment. In conclusion, reduction of p-tHcy by long-term n-3 PUFAs treatment was not associated with demonstrable effects on markers of endothelial adhesion properties.
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Grundt et al. (2003) conducted an RCT in Acute myocardial infarction (n=300). Highly concentrated n-3 polyunsaturated fatty acids (n-3 PUFAs) vs. Corn oil was evaluated on Plasma total homocysteine (p-tHcy), ultrasensitive C-reactive protein (microCRP), soluble E-selectin (sE-selectin), and soluble intercellular adhesion molecule-1 (sICAM-1) (p=0.022). Long-term n-3 PUFAs reduced plasma total homocysteine compared with corn oil at 1 year post-MI (p=0.022), without affecting endothelial adhesion markers or microCRP.
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