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The bromine determination (van der Meulen) has been adapted to the assay of bromisoval and carbromal in biological material. Interfering bromide is eliminated by pretreatment with silver nitrate. The ashing procedure was simplified by previous precipitation of proteins by acetone. Interference by bromine-containing metabolites of the drugs is absent or minimal. The method is applicable in the range of 0·1 to 1 μmol. Recovery in blood was 95%. The standard deviation of the determination is approximately 5%.
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A.G. Rauws (1969) studied this question.
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