Key result
Administration of MRS2578 exacerbated AAA rupture-induced mortality from 7% in controls to 21.4% (low dose) and 42.9% (high dose) (p < 0.05).
Why the study?
The P2Y6 receptor is involved in cardiovascular diseases, but its role in angiotensin II-induced abdominal aortic aneurysm formation remained to be explored.
Does the selective P2Y6 receptor antagonist MRS2578 prevent Angiotensin II-induced abdominal aortic aneurysm formation in apoE-/- mice?
Population
Male apoE -/- mice fed a high-fat diet
Comparison
MRS2578 (16 mg or 32 mg) vs Ang II plus vehicle vs normal saline
Design
Animal experimental study
Follow-up
4 weeks
Authors
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MRS2578 increases AAA rupture mortality in mice; leaves open P2Y6's role in human aneurysm stability.
Does the selective P2Y6 receptor antagonist MRS2578 prevent Angiotensin II-induced abdominal aortic aneurysm formation in apoE-/- mice?
Absolute Event Rate: 42.9% vs 7%
p-value: p=< 0.05
Administration of the P2Y6 receptor antagonist MRS2578 exacerbated the progression and rupture of experimental abdominal aortic aneurysms in mice, indicating a crucial role of the P2Y6 receptor in AAA development.
Du et al. (2020) studied Angiotensin II-induced abdominal aortic aneurysm (n=50). MRS2578 vs. Ang II + vehicle was evaluated on AAA rupture-induced mortality (p=< 0.05). Administration of MRS2578 exacerbated AAA rupture-induced mortality from 7% in controls to 21.4% (low dose) and 42.9% (high dose) (p < 0.05).
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