Comment on “Cutting Edge: Anti-CD25 Monoclonal Antibody Injection Results in the Functional Inactivation, Not Depletion, of CD4+CD25+ T Regulatory Cells”

The injection of anti-CD25 mAb to deplete CD25+ regulatory T cells (TR) in mice has been common practice to infer the function of TR. In a recent report, Kohm et al. ([1][1]) claimed that injection of anti-CD25 mAb in mice results in the functional inactivation, not depletion, of CD4+CD25+ TR. This