Why the study?
Do dogs with primary liver diseases have altered serum IGF-I concentrations compared to healthy dogs or those with non-hepatic diseases?
Do dogs with primary liver diseases have altered serum IGF-I concentrations compared to healthy dogs or those with non-hepatic diseases?
Dogs with liver diseases have significantly lower serum IGF-I concentrations compared to healthy dogs or those with non-hepatic diseases, similar to findings in humans.
May support canine liver disease evaluation; leaves open diagnostic utility and human parallels pending prospective validation.
Liver diseases are known to influence the serum concentration of insulin-like growth factor I (IGF-I) in humans, but such an effect has rarely been investigated in dogs. The aim of this study was to investigate serum IGF-I concentrations in dogs with primary liver diseases, in comparison with levels in healthy dogs and dogs with non-hepatic diseases. For this purpose, IGF-I serum concentrations were measured (DSL-5600 kit) in 36 dogs with various liver diseases and compared with 22 healthy controls and 20 dogs with non-hepatic diseases. The results showed that dogs with liver diseases had significantly lower IGF-I serum concentrations (P < 0.001) than clinical healthy dogs or dogs with non-hepatic diseases. But the results also indicate that the aetiology of liver disease has no influence on IGF-I serum concentration.
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Neumann et al. (2007) studied this question.
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