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October 12, 2013Journal of Biological ChemistryOpen Access

A Disintegrin and Metalloprotease (ADAM) 10 and ADAM17 Are Major Sheddases of T Cell Immunoglobulin and Mucin Domain 3 (Tim-3)

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Authors

KMKatja Möller‐HackbarthAsarina Pharma (Sweden)CDChristin DewitzUniversity Hospital Schleswig-HolsteinOSOlga SchweigertUniversität Hamburg

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Möller‐Hackbarth et al. (2013) studied this question.

synapsesocial.com/papers/6a7528d0f2cd31a1fadbfbc3https://doi.org/10.1074/jbc.m113.488478
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  3. 3Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways2011 · 293 citations
  4. 4ADAMs in cancer cell proliferation and progression2007 · 546 citations
  5. 5Anti-TIM3 Antibody Promotes T Cell IFN-γ–Mediated Antitumor Immunity and Suppresses Established Tumors2011 · 576 citations