Why the study?
The physiology of prominent prognostic factors in the cardiorespiratory system remains uncharted in Hans Chinese individuals, the world's largest ethnic group.
Does Hans Chinese ethnicity compared to European-American ethnicity affect peak oxygen uptake (VO2peak) and peak cardiac output (Qpeak) during incremental exercise in healthy adults matched for age, sex, and physical activity?
Does Hans Chinese ethnicity compared to European-American ethnicity affect peak oxygen uptake (VO2peak) and peak cardiac output (Qpeak) during incremental exercise in healthy adults matched for age, sex, and physical activity?
Answers are grounded in this paper and cite their sources.
Hans Chinese females exhibit a 16% lower peak oxygen uptake and 28% lower arteriovenous oxygen difference compared to physical activity-matched European-American females despite preserved cardiac output and enhanced resting diastolic function, suggesting that the prognostic value of VO2peak may require ethnic-specific reappraisal in Hans Chinese women.
Background The physiology of prominent prognostic factors in the cardiorespiratory system remains unchartered in the world's largest ethnic group: Hans Chinese (HC). This study assessed and contrasted the fundamental variables in HC and European-American (EA) individuals. Methods Healthy HC and EA adults ( n = 140, 43% ♀) closely matched by age, sex and physical activity were included. Body composition (DXA) and haematological variables (haemoglobin mass, blood volume (BV)) were measured at rest. Pulmonary O 2 uptake (VO 2 ) measurements along with cycle ergometry designed for accurate transthoracic echocardiography were implemented to assess cardiorespiratory structure/function up to peak effort. Findings HC presented with higher body fat and lower lean body mass (LBM) percentage than EA irrespective of sex ( P ≤ 0.014). BV did not differ whereas blood haemoglobin concentration was lower in HC compared with EA, particularly in females ( P = 0.009). Myocardial diastolic and overall function at rest was enhanced in HC versus EA ( P < 0.001). During exercise, heart volumes and output per unit of body size did not differ between ethnicities, whereas larger heart volumes per unit of LBM were found in HC versus EA in females ( P ≤ 0.003). At high exercise intensities, VO 2 (−16%) and the arteriovenous O 2 difference (−28%) were markedly reduced in HC compared with EA in females ( P ≤ 0.024). In males, no physiological difference between HC and EA was observed during exercise. Interpretation Notwithstanding lower LBM, HC are characterised by similar BV and cardiac capacity but reduced peak VO 2 than EA in females, partly explained by low ethnic-specific blood O 2 carrying capacity. Funding Early Career Scheme (106210224, to D.M.) and Seed Fund (104006024, to D.M.).
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Guo et al. (2023) studied this question.
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