Why the study?
Recent studies suggest lncRNA-H19 regulates key processes such as angiogenesis, lipid metabolism, and inflammation, but its roles and mechanisms in atherosclerosis require clearer understanding.
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Design
Review
lncRNA-H19 may regulate atherosclerosis processes; leaves open therapeutic targeting pending prospective validation.
Atherosclerosis (AS) is widely accepted to be a multistep pathophysiological process associated with several other processes such as angiogenesis and inflammatory response. Long non-coding RNAs (lncRNAs) are non-protein coding RNAs (more than 200 nucleotides in length) and can regulate gene expression at the transcriptional and post-transcriptional levels. Recent studies suggest that lncRNA-H19 plays important roles in the regulation of angiogenesis, adipocyte differentiation, lipid metabolism, inflammatory response, cellular proliferation and apoptosis. In this review, we primarily discuss the roles of lncRNA-H19 in atherosclerosis-related pathophysiological processes and the potential mechanisms by which lncRNA-H19 regulates the development of atherosclerosis, to help provide a better understanding of the biological functions of lncRNA-H19 in atherosclerosis.
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Shi et al. (2020) studied this question.
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