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April 1, 1973Proceedings of the National Academy of SciencesOpen Access

Membrane Sealing in Frog Skeletal-Muscle Fibers

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Population

Frog skeletal-muscle fibers

Comparison

Solutions rich in calcium ion vs Normal Ringer's solution

Design

Preclinical

Authors

WMWalmor C. De MelloNational Institutes of Health

Discussion

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Implication

Hypothesis-generating for calcium-phospholipid membrane repair; translation to mammalian injury or clinical use remains untested.

Structured PICO

P
Population
Frog skeletal-muscle fibers
I
Intervention
Solutions rich in calcium ion (or strontium, magnesium, phospholipase C, trypsin, chymotrypsin)
C
Comparator
Normal Ringer's solution
O
Outcome
Membrane self-sealingsurrogate

Calcium ions are essential for inducing membrane self-sealing in frog skeletal muscle fibers, a process dependent on membrane phospholipids.

Cite This Study

Walmor C. De Mello (1973) studied this question.

synapsesocial.com/papers/6a754aae96d04a2f43f589a6https://doi.org/10.1073/pnas.70.4.982
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electrical Phenomena in the Heart1977 · 78 citations
  2. 2A study of the mechanism of quantal transmitter release at a chemical synapse1968 · 195 citations
  3. 3The Effect of Calcium on the Skeletal Muscle Membrane after Treatment with Phospholipase C1968 · 20 citations