A chemical vision for the future of quantum materials: defect and interface engineering at the nanoscale

As we advance towards next-generation quantum technologies characterized by coherence, entanglement, and quantum control, chemistry is emerging as a critical enabler of quantum material innovation. This perspective explores how modern chemical strategies provide atomic-level control over material properties, allowing deterministic design of quantum states and interfaces. We highlight recent advances in spin-active molecules, quantum dots, two-dimensional materials, and hybrid platforms where chemistry shapes coherence, coupling, and device integration. Tools such as coordination chemistry, defect engineering, and surface passivation are shown to directly impact quantum behaviour, while chemical theory and spectroscopy enable deep insight into structure–function relationships. Through case studies ranging from strain-induced Rashba effects to single-atom manipulation, we illustrate how chemistry transcends traditional roles to become a central architect of quantum technologies. We argue for a new paradigm of ‘quantum-informed chemistry’ as essential for designing scalable, high-fidelity systems for quantum sensing, computation, and communication.