Key result
Apolipoprotein E E4 allele number increased familial and sporadic Alzheimer's disease risk in both men and women among 234 members of 42 families older than 60 years.
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To the Editor. —Recently, Dr Payami and colleagues proposed a difference in Alzheimer's disease (AD) risk between men and women who have one copy of the apolipoprotein E (apo E) E4 allele.¹Specifically, they suggested that men with no or one copy ofE4(theE2/E2, E2/E3, E3/E3, E2/E4, andE3/E4genotypes) have a decreased risk of AD compared with men with two copies (theE4/E4genotype), while women with no copy ofE4have a decreased risk of AD compared with those with one or two copies. Our studies do not suggest this sex-specific pattern of risk.²,³We find instead that risk of AD, both familial and sporadic (ie, no family history), increases with the number ofE4alleles in men and women. TheE4gene dose effect was initially found in 234 members of 42 AD families older than 60 years and can be seen when
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Elizabeth H. Corder (1995) conducted a letter in Alzheimer's disease (n=234). Apolipoprotein E E4 allele (1 or 2 copies) vs. No copy of the apolipoprotein E E4 allele was evaluated on Risk of familial and sporadic Alzheimer's disease. Apolipoprotein E E4 allele number increased familial and sporadic Alzheimer's disease risk in both men and women among 234 members of 42 families older than 60 years.
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