Why the study?
Does pulsed magnetic stimulation modify the amplitude of action potentials in sciatic nerve segments in vitro?
Does pulsed magnetic stimulation modify the amplitude of action potentials in sciatic nerve segments in vitro?
Pulsed magnetic fields enhance the amplitude of compound action potentials in vitro via an ion channel-dependent mechanism.
Should not yet alter clinical neuromodulation practice; hypothesis-generating for PMF effects on nerve excitability in vitro.
This paper investigates the influence of pulsed magnetic fields (PMFs) on amplitude of evoked, compound action potential (CAP) recorded from the segments of sciatic nerve in vitro. PMFs were applied for 30 min at frequency of 0.16 Hz and intensity of 15 mT. In confirmation of our previous reports, PMF exposure enhanced amplitude of CAPs. The effect persisted beyond PMF activation period. As expected, CAP amplitude was attenuated by antagonists of sodium channel, lidocaine, and tetrodotoxin. Depression of the potential by sodium channels antagonists was reversed by subsequent exposure to PMFs. The effect of elevated potassium concentration and veratridine on the action potential was modified by exposure to PMFs as well. Neither inhibitors of protein kinase C and protein kinase A, nor known free radicals scavengers had any effects on PMF action. Possible mechanisms of PMF action are discussed.
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Ahmed et al. (2015) studied this question.
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