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The changes occurring in the ionic, bound, and total fluoride contents of plasma and muscle from rats shifted from low fluoride intake to high fluoride intake and back to low fluoride intake were examined. Approximately 10 days were required for the reequilibration of the ionic and total fluoride levels of plasma and muscle following changes in the dietary fluoride intake. Data have been obtained that show the systematic changes produced in the bound fraction of plasma and muscle fluoride by variations in dietary fluoride intake.
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Ophaug et al. (1977) studied this question.
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