Propranolol

Comments and Corrections1 November 1973PropranololWILLIAM B. ABRAMS, M.D., F.A.C.P.WILLIAM B. ABRAMS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-5-752 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The principal point of the recent article by Morrelli on propranolol (Ann Intern Med 78:913-917, 1973) is that the package insert is out of date. He appears to be concerned principally with new indications recommended in the literature but not included in this document. . . . I share Dr. Morrelli's opinion that the package insert does not reflect certain uses currently "unapproved."Unfortunately, some of his statements are also a bit out of date. For example, he notes that "new drugs . . . are often introduced after only limited clinical trials. . . ." Surely...References1. COLTART D and SHAND D: Plasma propranolol levels in the quantitative assessment of β-adrenergic blockade in man. Br Med J 3:731-734, 1970 CrossrefMedlineGoogle Scholar2. COLTART D, GIBSON D, and SHAND D: Plasma propranolol levels associated with suppression of ventricular ectopic beats. Br Med J 1:490-491, 1971 CrossrefMedlineGoogle Scholar3. GIBSON D, BALCON R, and SOWTON E: Clinical use of I.C.I. 50172 as an antidysrhythmic agent in heart failure. Br Med J 3:161-163, 1968 CrossrefMedlineGoogle Scholar4. SHAND D and RANGNO R: The disposition of propranolol. Pharmacology 7:159-168, 1972 CrossrefMedlineGoogle Scholar5. ZACEST R and KOCH-WESER J: Relation of propranolol plasma level to beta blockade during oral therapy. Ibid., pp. 178-185 Google Scholar6. ADELMAN A, SHAN P, and GRAMIAK R: Long-term propranolol therapy in muscular subaortic stenosis. Br Heart J 32:804-811, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM B. ABRAMS, M.D., F.A.C.P.Affiliations: Ayerst Laboratories New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySynthesis of Condensed and Uncondensed Tetrazolo[1,5-b][1,2,4]triazines as Potential Antimicrobial AgentsD 1 November 1973Volume 79, Issue 5Page: 752-754KeywordsClinical trialsDrugs ePublished: 1 December 2008 Issue Published: 1 November 1973 PDF downloadLoading ...