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Determining changes in the composition of cell populations is made possible by technologies like single-cell transcriptomics, CyTOF, and microbiome sequencing. However, existing methods for differential abundance do not model some ...Cellular omics such as single-cell genomics, proteomics, and microbiomics allow the characterization of tissue and microbial community composition, which can be compared between conditions to identify biological drivers. This strategy has been critical to ...
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Hofmeyer et al. (2008) studied this question.
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