Key result
Post-stroke monocytes transition into persistent microglia-like cells expressing microglial markers for at least ~62 days.
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parenchymal microglia in selective brain regions at P24. Furthermore, this fate mapping strategy revealed an acute influx of monocytes after neonatal stroke, which gradually transformed into a ramified morphology and expressed microglial marker genes (Sall1, Tmem119, and P2RY12) for at least 62 days after injury. These results suggest an underappreciated level of monocyte-to-microglia transition in development and after neonatal stroke.
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Chen et al. (2020) studied Neonatal stroke. Fate mapping via CCR2-CreER mice was evaluated on Monocyte-to-microglia transition and expression of microglial marker genes (Sall1, Tmem119, P2RY12). Fate mapping via CCR2-CreER mice revealed monocyte-to-microglia transition at P24 and persistent microglial marker expression for at least 62 days after neonatal stroke.
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