Objective: Glucagon-like peptide-1 receptors agonists (GLP-1 RAs) are adjunctive treatment for patients with diabetes. The mechanism of action is to increase insulin and decrease glucagon secretion along with delay of gastric emptying which has superior effect toward post-prandial blood glucose level. However, the GLP-1RAs effect on gastric emptying (GE) on patients with compromised gastric motility, especially in diabetes patients, is not well-documented. The aim of this systematic review is to determine the effects of GLP-1 RAs on gastric motility in healthy subjects, diabetic type 1 and type 2 patients and to identify the specific conditions that could alter these effects.
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Wongjarupong et al. (2020) studied this question.
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