Mouse strains vary in their production of ascitic fluid. Intraperitoneal injections of heat-killed Staphylococcus aureus-incomplete Freund's adjuvant mixtures induce early development of ascites. Yield of ascitic fluid may be greater with adjuvant alone but production is often delayed. Yield in individual mice may be very large. High late yield for BALB/cAnN mice receiving only adjuvant are associated with occurrence of plasma cell tumors.
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Lieberman et al. (1961) studied this question.