The idea that eukaryotic enhancers and promoters have a modular structure is now generally accepted (Serfling et al. 1985; Yamamoto 1985; Maniatis et al. 1987). According to this view, short cis-control sequence elements are the basic units that build up transcriptional regulatory regions. These so-called “promoter modules” differ in their regulatory function and responsiveness to extranuclear signals. Thus, a particular combination of regulatory modules confers promoter specificity and programs the transcriptional properties of the linked gene. One example of such a regulatory module is the AP-1-binding site originally found in the enhancers of SV40 and the human MTIIA gene (Lee et al. 1987b). Subsequently, AP-1 recognition elements were identified in a wide range of other viral and cellular transcriptional control regions. All AP-1-binding sites contain the palindromic sequence, TGACTCA, or a close variant thereof. These sites can apparently function as basal-level promoter elements, and in certain cell types, transcription can...
No takes yet. Share an insight, caveat, or question.
Bohmann et al. (1988) studied this question.