Hyperalimentation in Primates. A Nutritional Model

To establish the subhuman primate as an effective laboratory animal in parenteral nutrition research, 18 male macaque monkeys were adapted to chronic chair restraint and maintained on intravenous nutrition for 1- and 2-week periods. The animals remained in the restraint chairs for 11.6 +/- (2.3) weeks and the inferior vena cava catheters remained for 53 +/- (7.8) days. Catheter and metabolic complications during intravenous nutrition infusion were few and morbidity was low. The animals maintained weight, serum albumin, and serum transferrin levels as well as a positive nitrogen balance during the study period. The macaque is a highly suitable model for nutritional studies requiring a controlled environment during long-term studies.