Why the study?
Neonatal lupus frequently manifests as congenital heart block that can progress after birth, but underlying atrioventricular node zone pathology warrants description.
Demonstrates rare histopathological findings of cartilaginous metaplasia, fibrosis, and calcification in the AV node of a neonate with complete heart block due to neonatal lupus.
Case of AV nodal metaplasia in neonatal lupus block; leaves open mechanistic and preventive research questions.
Neonatal lupus is a rare disease associated with the circulation in the mother’s blood of one or more autoantibodies to soluble intracellular ribonucleoproteins Ro/SS-A and La/SS-B. This disease is extremely often manifested by congenital heart block, which can progress even after the birth of a child. We have described a case of fibrosis, calcification and cartilaginous metaplasia of the atrioventricular node zone, which caused complete atrioventricular block in a child who died from neonatal lupus.
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Davydov et al. (2023) studied this question.
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