Why the study?
Does aspirin contribute to or protect against intracranial hemorrhage in patients with Sturge-Weber syndrome?
Does aspirin contribute to or protect against intracranial hemorrhage in patients with Sturge-Weber syndrome?
This case report highlights the need for further data to understand the safety and utility of aspirin regarding intracranial hemorrhage risk in patients with Sturge-Weber syndrome.
May warrant caution with aspirin in Sturge-Weber syndrome after minor trauma; leaves open net benefit and requires prospective study.
Sturge-Weber syndrome is a neurocutaneous disorder associated with vascular abnormalities in the skin, eye, and brain leading to both acute and chronic cerebral hypoperfusion and, in some affected children, brain injury. Aspirin can reduce stroke-like events and seizure episodes and prevent further brain injuries in these patients. Although a few cases of intracranial hemorrhage in patients with Sturge-Weber syndrome have been reported, prior reports have not discussed this complication with regard to particular therapies. The authors present a toddler with Sturge-Weber syndrome who developed a subdural hematoma in the setting of a mechanical fall with minor head trauma. They discuss the possible role of aspirin in contributing to, or perhaps protecting against, intracranial hemorrhage in patients with Sturge-Weber syndrome. Further data are needed to establish the utility of aspirin in Sturge-Weber syndrome.
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Lopez et al. (2012) studied this question.
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