Peptide-Based Supramolecular Semiconductor Nanomaterials via Pd-Catalyzed Solid-Phase “Dimerizations”

We report a streamlined method for the synthesis of peptides embedded with complex and easily variable π-conjugated oligomeric subunits from commercially available precursors. These modified peptides self-assemble under aqueous conditions to form one-dimensional nanomaterials containing networks of π-stacked conduits, despite the inclusion of π-conjugated oligomers with quadrupoles extended over larger areas. The procedure has circumvented solubility and other synthetic issues to allow for the facile formation of a diverse library of bioelectronic nanomaterials, including a complex sexithiophene-containing peptide whose nanostructures display gate-induced conductivity within field effect transistors.