Key result
Women show higher glucose and insulin responses during OGTT, while men exhibit greater glucagon suppression.
Observational (n=63)
It has been reported that glucose responses during the oral glucose tolerance test differ between healthy women and men. However, it remains unknown what factors contribute to these differences between the sexes. The present study analyzed the insulin and glucagon responses during the oral glucose tolerance test in 25 female and 38 male healthy young adults aged 22-30 years. The plasma glucose levels at 120 min were significantly higher in women than men. Insulin secretion was significantly greater at 30, 90 and 120 min from baseline in women than men. Glucagon suppression was greater at 30 and 120 min from baseline in men than women when determined by a sandwich enzyme-linked immunosorbent assay glucagon kit. These results suggest that the differences in glucose responses during the oral glucose tolerance test are mediated by the difference between the sexes in bi-hormonal responses in healthy individuals.
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Horie et al. (2018) conducted an observational in Glucose homeostasis in healthy young adults (n=63). Female sex vs. Male sex was evaluated on Plasma glucose, insulin secretion, and glucagon suppression during oral glucose tolerance test. Healthy women had significantly higher 120-min plasma glucose and greater insulin secretion (30, 90, 120 min), while men had greater glucagon suppression (30, 120 min) during OGTT.
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