Why the study?
Adjuvants such as fentanyl and magnesium have been added to hyperbaric bupivacaine for spinal anaesthesia in an attempt to prolong analgesia.
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Population
70 patients of either gender
Comparison
Intrathecal bupivacaine, fentanyl, and magnesium sulphate vs bupivacaine, fentanyl, and normal saline
Design
Randomized study
Local anaesthetics with additives in a wide range, affect the versatility of spinal anaesthesia. Amongst a diverse class of drugs, phenylpiperidine derivative fentanyl, NMDA receptor blocker magnesium have been added as adjuvants to amide local anaesthetic hyperbaric bupivacaine for spinal anaesthesia in an attempt to prolong analgesia. METHODS 70 patients of either gender were selected randomly and were divided into two groups of 35 each. Administered intrathecally in Group S (control) 12.5 mg of hyperbaric bupivacaine, 25 mcg of fentanyl, 1 mL of normal saline and in Group M (study) 12.5 mg of hyperbaric bupivacaine, 25 mcg of fentanyl, 50 mg of magnesium sulphate.
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Sen et al. (2020) studied this question.
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