Several heterocycles containing N ‐hydroxylamine were prepared and tested as coupling additives to replace the use of N ‐hydroxybenzotriazole (HOBt) derivatives. On the basis of our results on coupling yield and racemization‐suppressing properties, we propose N ‐hydroxyindolin‐2‐one and 6‐chloro‐ N ‐hydroxy‐2‐phenylbenzimidazole as suitable substitutes for HOBt.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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El‐Faham et al. (2009) studied this question.
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