Early Clinical Indicators of Metabolic Syndrome and Insulin Resistance in A Cohort of Greek Children with Obesity

This is the authors' abstract. We don't add key points for this paper.

Results: IR, as indicated by Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) of ≥ 3, was present in 33.3% of the children, while 12.7% of them met the criteria for Mets. The mean BMI was greater in children with IR (p < 0.001). Also, children with IR had greater Waist Circumference (WC) (p < 0.001). Acanthosis nigricans (p = 0.041) and increased fat percentage (p = 0.003) were associated with greater likelihood for IR. WHtR was associated with greater odds for IR (p = 0.048). Among children with MetS, 54.2% had IR and they were all affected by obesity. Increased WC was associated with the presence of MetS (p = 0.046), while for one unit increase in BMI the likelihood for MetS was found to increase about 14% (p = 0.001).