Mice injected bitemporally with puromycin 5 hours before training learned to escape or to avoid shock by choosing the correct limb of a Y-maze. When retested 15 minutes after training they had normal retention. In the ensuing 2(3/4) hours the animals injected with puromycin, unlike the controls, showed a progressive decrease of savings to less than 7 percent.
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Barondes et al. (1966) studied this question.
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