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Bacterial polysaccharides prolong plasma coagulation time similar to heparin, with greater effects in thrombocytopenia.
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Bacterial polysaccharides from cultures of Friedländer’s bacillus and Serratia marcescens (Shear’s P-25) tend to prolong the coagulation time of diluted plasma in vitro. This activity appears to be parallel to, but limited with respect to, that of heparin. The anticoagulant effect of bacterial polysaccharide as well as that of heparin is likely to be enhanced in thrombocytopenic plasma of children with acute leukemia.
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GUSTAVE FREEMAN (1952) studied Acute leukemia with thrombocytopenia. Bacterial polysaccharides from Friedländer's bacillus and Serratia marcescens (Shear's P-25) vs. Heparin was evaluated on Coagulation time of diluted plasma in vitro. Bacterial polysaccharides from Friedländer's bacillus and Serratia marcescens prolonged in vitro plasma coagulation time parallel to heparin, with enhanced effects in thrombocytopenic leukemic plasma.
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