Suppositories containing sodium phenobarbitone (200 mg) were manufactured with the following bases; cocoa butter, cocoa butter plus beeswax, Dehydag and polyethylene glycols. The release of sodium ions through a dialysis membrane was conveniently measured with a sodium-specific ion electrode. The method facilitates evaluation and comparison of suppository bases and allows continuous monitoring of the release of active ingredient.
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Thomas et al. (1971) studied this question.
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