Why the study?
Whether the physiological functions of S1P require chaperones is not clear.
Population
ApoM-deficient, albumin-deficient, and double-KO (DKO) mice
Authors
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DKO mice viability indicates compensatory S1P chaperones; leaves open redundancy in human vascular and immune signaling.
ApoA4 acts as a novel chaperone for sphingosine 1-phosphate, maintaining essential extracellular signaling and vascular endothelial barrier function in the absence of ApoM and albumin.
Obinata et al. (2019) studied this question.
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