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• Size of STING ligand nanocomplexes (NCs) is pH dependent, being 6-fold bigger than that of lysosomes at low pH. • Macrophage polarization from M2 to M1 upon STING ligand delivery might improve immune infiltration of cold tumors. • Biocompatibility and toxicity was assessed by hen egg CAM model. • Performed pilot in vivo STING ligand intratumoral administration studies on established B16.F10 tumor in mice.
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Petrovic et al. (2023) studied this question.
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