Why the study?
Does a pulsed Doppler velocimeter accurately measure brachial artery hemodynamics and response to intravenous nitroglycerin in healthy men?
Does a pulsed Doppler velocimeter accurately measure brachial artery hemodynamics and response to intravenous nitroglycerin in healthy men?
The described pulsed Doppler velocimeter provides an accurate noninvasive method for determining volumic flow and pharmacological responses in peripheral arteries.
Answers are grounded in this paper and cite their sources.
May support noninvasive brachial flow assessment in research; leaves open clinical validation in larger or diseased cohorts.
A pulsed Doppler velocimeter suitable for the determination of blood flow velocity and volumic flow in peripheral arteries is described. The apparatus has two main characteristics: an adjustable range-gated time system and a double transducer probe. The error in the determination of the angle between the ultrasound beam and flow of blood with this apparatus was less than 2%, and overestimation of the arterial diameter due to the sample volume size did not exceed 0.035 +/- 0.015 cm. The apparatus was used to determine diameter, blood flow velocity and volumic flow of the brachial artery of 22 healthy men. The values were respectively 0.440 +/- 0.010 cm, 9.15 +/- 1.01 cm.s-1 and 85 +/- 10 cm3.min-1. Administration of intravenous nitroglycerin significantly increased the arterial diameter (p less than 0.001) without any significant change in volumic flow. The described pulsed Doppler velocimeter provides an accurate noninvasive method for determining volumic flow in peripheral arteries in clinical investigation and cardiovascular pharmacology.
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Levenson et al. (1981) studied this question.
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