Sequence‐Unrestricted, Watson–Crick Recognition of Double Helical B‐DNA by (R)‐MiniPEG‐γPNAs

Invasion of the strand snatchers: We have synthesized chiral γ-peptide nucleic acids containing miniPEG side chains. Using gel shift assays we show that this particular type of nucleic acid mimic can invade any sequence of double helical B-form DNA (see figure), and this recognition occurs through direct Watson–Crick base pairing.