Clinicians should be aware that ACE inhibitors can cause intestinal angioedema presenting as acute abdominal pain, which resolves upon drug discontinuation.
Sir, Angioedema of the lips, tongue, and glottis as an adverse reaction to angiotensin-converting enzyme (ACE) inhibitors was recently highlighted in this journal.1 We wish to add that intestinal angioedema is a well-documented side-effect of ACE inhibitor therapy.2 Patients may present with acute abdominal pain, nausea, and vomiting and abdominal distension. This is usually associated with angioedema of the tongue, pharynx and larynx. Symptoms usually resolve within 24 hours after discontinuation of the ACE inhibitor. Early onset of ACE-inhibitor-induced angioedema should not pose …
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Kashyap et al. (1999) studied this question.
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