Why the study?
Do antiplatelet drugs inhibit atherogenesis?
Population
Experimental models of arterial endothelial injury (primates) and humans
Design
Review
Authors
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Provides mechanistic rationale for antiplatelet therapy in atherosclerosis; leaves open whether this reduces clinical events in humans.
Do antiplatelet drugs inhibit atherogenesis?
This review highlights the critical role of platelet-derived mitogens in smooth muscle cell proliferation and atherogenesis, providing a mechanistic rationale for antiplatelet therapy.
Harker et al. (1976) studied this question.
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