Guidance reveals challenges in achieving statistical precision in hypothesis testing for clinical assessments, suggesting implications for Member States.
The European Health Technology Assessment (EU HTA) guidance on Multiplicity of Hypothesis Testing (MHT) [1] resembles an algebra no-solution equation. The hypothetico-deductive method used in inferential statistics, which this guidance references, relies on conclusive reasoning. However, the guidance fails to provide a clear resolution, leaving the matter to individual Member States (MS) despite its critical impact on statistical precision, a key pillar of validity in clinical trials for comparative effectiveness assessments in Joint Clinical Assessments (JCAs)
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Toumi et al. (2026) studied this question.
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