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March 24, 2003Antimicrobial Agents and Chemotherapy186 citationsOpen Access

Imipenem Resistance in a Salmonella Clinical Strain Due to Plasmid-Mediated Class A Carbapenemase KPC-2

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VMVivì MiriagouLTL. S. TzouvelekisSRShannon Rossiter

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Abstract

A Salmonella enterica serotype Cubana isolate exhibiting resistance to most beta-lactam antibiotics, including oxyimino-cephalosporins and imipenem, was isolated from a 4-year-old boy with gastroenteritis in Maryland. beta-Lactam resistance was mediated by a conjugative plasmid that encoded KPC-2, a class A carbapenemase previously found in a Klebsiella pneumoniae isolate from the Maryland area as well. Sequence analysis of the flanking regions indicated a potential association of bla(KPC-2) with mobile structures.

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Miriagou et al. (2003) studied this question.

synapsesocial.com/papers/6a758ba8e42ca79ec1e72653https://doi.org/10.1128/aac.47.4.1297-1300.2003
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