Key result
Integrative review develops a middle-range theory identifying clinical antecedents of fatigue in CKD.
Why the study?
To develop a middle-range theory on the phenomenon of fatigue in individuals with chronic kidney disease.
Provides a conceptual framework for fatigue in chronic kidney disease to support clinical reasoning and nursing interventions.
Theory on fatigue in CKD is hypothesis-generating; leaves open validation before informing care or research.
This study aimed to develop a middle-range theory (MRT) on the phenomenon of fatigue in individuals with chronic kidney disease. It was a methodological study, conducted through an integrative literature review in Scopus, SciELO, and PubMed databases, which included 41 studies. The theory was developed in five steps: defining the theoretical approach, identifying core concepts, establishing causal relationships supported by clinical practice, designing a representative pictogram, and constructing explanatory propositions. This MRT includes 5 essential attributes, 13 clinical antecedents, 9 empirical referents, and 8 propositions, providing a conceptual framework that strengthens clinical reasoning and supports more precise nursing interventions.
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Menezes et al. (2026) conducted a review in Chronic kidney disease (n=41). An integrative literature review of 41 studies developed a middle-range theory on fatigue in chronic kidney disease, identifying 5 essential attributes, 13 clinical antecedents, and 8 propositions.
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