Value of lncRNA SNHG1 targeted regulation of miR-16-5p in diagnosis and prognosis of patients with aortic dissection

Q: What are the key findings of this study?

Low serum expression of lncRNA SNHG1 was significantly associated with poorer 30-day survival in patients with aortic dissection (HR 3.069, p=0.015).

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Aortic dissection (n=208). Intervention: Low lncRNA SNHG1 expression vs. High lncRNA SNHG1 expression. Primary outcome: 30-day survival (HR 3.069, p=0.015).

Q: What does this research mean for the field?

Low expression of lncRNA SNHG1 is significantly associated with poorer survival and serves as a diagnostic and prognostic biomarker in aortic dissection via targeting miR-16-5p. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Jiangang Guo; Zhida Yin; Zunrong Liu; Yunjie Hu

doi:10.1186/s13019-026-04645-1

August 5, 2026Journal of Cardiothoracic SurgeryOpen Access

Value of lncRNA SNHG1 targeted regulation of miR-16-5p in diagnosis and prognosis of patients with aortic dissection

View Full Paper

Ask AI

Bookmark

Share

Key result

Low serum lncRNA SNHG1 is linked to ~3-fold higher 30-day mortality in aortic dissection.

HR 3.069
P=0.015
n=208

Why the study?

LncRNA SNHG1 is abnormally expressed in aortic dissection patients, but its specific mechanism and prognostic value remain unclear.

Does lncRNA SNHG1 expression predict diagnosis and 30-day prognosis in patients with acute aortic dissection?

Key Points

Investigate the clinical diagnostic and prognostic value of lncRNA SNHG1 in patients with aortic dissection and clarify its molecular mechanism involving miR-16-5p in vascular smooth muscle cells.
Quantified serum lncRNA SNHG1 expression in aortic dissection (AD) patients and healthy controls using RT-qPCR, assessing diagnostic utility with ROC curve analysis and survival using Kaplan-Meier curves and Cox regression.
Evaluated vascular smooth muscle cell (VSMC) proliferation (CCK-8) and apoptosis (flow cytometry) after lncRNA SNHG1 overexpression, validating direct binding to miR-16-5p using dual-luciferase reporter assays.
Serum lncRNA SNHG1 expression was significantly lower in AD patients than controls (P < 0.001), demonstrating diagnostic capacity with an AUC of 0.902 (sensitivity = 0.9038, specificity = 0.7885).
Patients with low SNHG1 expression (n = 54) had worse survival than those with high expression (n = 50), with SNHG1 independently predicting AD prognosis (HR = 3.069, P = 0.015).
Overexpression of SNHG1 enhanced VSMC proliferation and suppressed apoptosis, whereas direct targeting and up-regulation of miR-16-5p reversed these cellular effects.

Study Design

Type

Observational (n=208)

Multicenter

No

Structured PICO

Does lncRNA SNHG1 expression predict diagnosis and 30-day prognosis in patients with acute aortic dissection?

P

Population

208 participants, including 104 patients with acute aortic dissection and 104 healthy controls, followed for 30 days to evaluate the diagnostic and prognostic value of lncRNA SNHG1.

C

Comparator

Healthy controls

O

Outcome

Diagnostic value (ROC AUC) and 30-day prognosis (survival) based on lncRNA SNHG1 expressionsurrogate

Main Result

Hazard Ratio: 3.069

p-value: p=0.015

LncRNA SNHG1 is downregulated in aortic dissection and may serve as a diagnostic and prognostic biomarker, potentially regulating vascular smooth muscle cell function via miR-16-5p.

Limitations

Single-center design
Relatively small sample size
Potential confounding factors such as comorbidities and medication use were not fully explored
single-center design
relatively small sample size
potential confounding factors such as comorbidities and medication use were not fully explored

Implication

SNHG1 downregulation aids AD diagnosis and prognosis; leaves open clinical utility pending larger prospective validation.

Abstract

Aortic dissection (AD) is a critical macrovascular emergency related to the morphology of vascular smooth muscle cell (VSMC). LncRNA SNHG1 is abnormally expressed in AD patients, but its specific mechanism and prognostic value remain unclear. This study investigated lncRNA SNHG1 expression, diagnostic and prognostic value in AD. RT-qPCR detected lncRNA SNHG1 expression in AD patients. ROC evaluated diagnostic value. Kaplan-Meier curve and Cox Proportional Hazards Regression Model analyzed prognostic value. Cell counting kit 8 (CCK-8) determined cell activity, flow cytometry measured apoptosis, and luciferase reporter gene analysis identified lncRNA SNHG1-miR-16-5p targeting. LncRNA SNHG1 expression in AD patients was clearly lower than that in controls ( P < 0.001), and negatively correlated with AD risk score. LncRNA SNHG1 exhibited diagnostic and prognostic value in AD. In vitro, overexpression of lncRNA SNHG1 promoted VSMCs proliferation and inhibited apoptosis. Luciferase reporter genes showed that lncRNA SNHG1 directly targeted miR-16-5p, with negative correlation. Up-regulation of miR-16-5p reversed the pro-proliferative and anti-apoptotic effects of lncRNA SNHG1. LncRNA SNHG1 may participate in the pathogenesis of AD by targeting miR-16-5p and become a potential diagnostic biomarker for AD.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Guo et al. (2026) conducted an observational in Aortic dissection (n=208). Low lncRNA SNHG1 expression vs. High lncRNA SNHG1 expression was evaluated on 30-day survival (HR 3.069, p=0.015). Low serum expression of lncRNA SNHG1 was significantly associated with poorer 30-day survival in patients with aortic dissection (HR 3.069, p=0.015).

synapsesocial.com/papers/6a758be1847ab6d26c01f687 https://doi.org/10.1186/s13019-026-04645-1

View Full Paper

Ask AI

Bookmark

Share

Value of lncRNA SNHG1 targeted regulation of miR-16-5p in diagnosis and prognosis of patients with aortic dissection

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Value of lncRNA SNHG1 targeted regulation of miR-16-5p in diagnosis and prognosis of patients with aortic dissection

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading