Left ventricular remodeling following parathyroidectomy in uremic secondary hyperparathyroidism

Parathyroidectomy (PTX) improves left ventricular structure and geometry in patients with uremic secondary hyperparathyroidism (SHPT). This single-center retrospective study followed 131 patients through December 31, 2022, and compared echocardiographic parameters before surgery and one year postoperatively. PTX significantly reduced the proportion of patients with moderate-to-severe left ventricular hypertrophy. Additionally, 26.19% of patients with preoperative concentric hypertrophy transitioned to normal geometry or concentric remodeling after surgery. Elevated postoperative systolic blood pressure was identified as an independent risk factor for deterioration in left ventricular geometric configuration (LVGC), whereas higher hemoglobin and serum albumin levels were associated with a lower risk of LVGC changes. These findings suggest that PTX may have cardioprotective effects in patients with uremic SHPT.