Theoretical model examines consciousness through genome architecture, suggesting new insights into cognition.
The central problem in consciousness science is the lack of an identified material carrier of subjective experience. In the proposed model, this carrier is the three-dimensional architecture of the genome in postmitotic neurons of the cortex and hippocampus. The dual organization of the genome has two polar strategies: the conservative strategy of somatic cells (C1), aimed at maintaining the body, and the plastic strategy of neurons (C2), generating reflection. Their interaction generates the duality of consciousness. The integrity of the system is maintained by the coordinated dynamics of genomes based on the similarity of their topologies. The C1/C2 model offers tests for experimental verification, formulates the concept of topological therapy, and principles for strong artificial intelligence. Consciousness is presented as a natural stage of genome evolution, implementing the transition from a biological form of existence to postbiological cognitive systems. A transition from dualism to monism is proposed, where consciousness and the body are two strategies of a single genomic substance.
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Bodygin et al. (2026) studied this question.
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