Efficacy of Working Memory training on Craving and Cognitive Functioning of Opiate Users

Objective:The aim of this study was to examine the efficacy of computer-assisted cognitive rehabilitation treatment (CACRT), working memory training, as a complementary treatment of opiate craving in-patients with substance use disorder.Methods: Thirty opiate users receiving methadone maintenance treatment (MMT) were randomly allocated to two groups: MMT plus CACRT for the experimental group and standard methadone treatment only for the control group.In the experimental group, participants received 15 sessions of CACRT.All participants in both groups were assessed on measures of craving, impulsivity, delay discounting, and risky decision making at baseline and after treatment completion.Results: Participants in the experimental group showed significant working memory improvements as well as craving reductions, accompanied by a positive effect on impulsivity and delay discounting.However, there was no significant difference in terms of risky decision-making between participants from the experimental group and participants from the control group. Conclusion:These results suggest improvement of working memory has positive effects on impulsivity, delay discounting ability, and craving reduction.