What question did this study set out to answer?

This study aims to assess if the Kidney Failure Risk Equation accurately reflects renal vulnerability in adults with sickle cell disease.

August 7, 2026Renal FailureOpen Access

Kidney failure risk equation and early renal risk in adults with sickle cell disease: comparison with KDIGO classification using measured GFR

View Full Paper

Ask AI

Bookmark

This study aims to assess if the Kidney Failure Risk Equation accurately reflects renal vulnerability in adults with sickle cell disease.
Multicenter cross-sectional study in Kinshasa with 241 adults with stable sickle cell disease.
Measured glomerular filtration rate (mGFR) and assessed albuminuria.
Classified renal risk using KDIGO criteria and calculated KFRE.
35.7% of participants had moderate-to-high KDIGO renal risk, despite low KFRE estimates.
Median KFRE risk increased for CKD stage ≥3 to 5.98% at 2 years and 10.14% at 5 years.
Factors associated with increased renal risk included vaso-occlusive crises (aOR 2.80, p = 0.012) and elevated LDH >220 U/L (aOR 3.19, p = 0.006).

No takes yet. Share an insight, caveat, or question.

Cross-sectional study evaluates renal risk in adults with sickle cell disease using KFRE and KDIGO classification.

Engole et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark