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September 16, 2009Proceedings of the National Academy of SciencesOpen Access

Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation

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Population

Primary excitable cells (including skeletal and smooth muscle, heart, brain, kidney, and pancreas)

Comparison

Evaluation of the Kir6.2 C-terminal AnkB-binding… vs Kir6.2 lacking the AnkB-binding motif

Design

Preclinical

Authors

CKCrystal F. KlineHKHarley T. KurataTHThomas J. Hund

Discussion

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Overview

Animal data on Kir6.2-AnkB interactions do not alter clinical practice; leaves open therapeutic targeting in human channelopathies.

Structured PICO

P
Population
Primary excitable cells (including skeletal and smooth muscle, heart, brain, kidney, and pancreas)
I
Intervention
Evaluation of the Kir6.2 C-terminal AnkB-binding motif (ABM)
C
Comparator
Kir6.2 lacking the AnkB-binding motif
O
Outcome
K(ATP) channel membrane targeting and metabolic regulationsurrogate

The K(ATP) channel AnkB-binding motif is a critical bifunctional element for channel gating and membrane targeting, with implications for excitable cell metabolic regulation and disease.

Cite This Study

Kline et al. (2009) studied this question.

synapsesocial.com/papers/6a758dd29384a185e25ffc3fhttps://doi.org/10.1073/pnas.0907138106
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